Are allergen batch differences and the use of double skin prick test important?

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Are allergen batch differences and the use of double skin prick test important?

BACKGROUND Skin prick tests (SPT) are widely used both in clinical diagnostics and in research. The standardization of allergen extracts is well documented to be crucial for the validity of SPT, whereas less emphasis has been placed on reproducibility and the SPT procedure itself. The objectives of this study are to clarify how the double skin prick test procedure influence the sensitivity and ...

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Time course of the inflammatory response to histamine and allergen skin prick test in guinea-pigs.

Plasma exudation and vasodilatation are key microvascular features of acute inflammation. Exudation and vasodilatation responses in the weal area after skin prick testing with histamine are essentially completed within 30 min. There is evidence to suggest that vasodilatation lasts considerably longer after provocation with allergen, but there is no information on the duration of plasma exudatio...

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Allergen skin prick test should be adjusted by the histamine reactivity.

BACKGROUND Skin prick test results are mostly reported as mean wheal diameter obtained with one concentration of allergen. Differences in technique between personnel causes variation in wheal size. The research question was whether the influence of differences in skin prick test technique among assistants and centers can be reduced by relating the allergen wheal response to that of histamine. ...

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The skin prick test – European standards

Skin prick testing is an essential test procedure to confirm sensitization in IgE-mediated allergic disease in subjects with rhinoconjunctivitis, asthma, urticaria, anapylaxis, atopic eczema and food and drug allergy. This manuscript reviews the available evidence including Medline and Embase searches, abstracts of international allergy meetings and position papers from the world allergy litera...

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Allergen Skin Prick Test Should Be Adjusted by the Histamine Reactivity

Background: Skin prick test results are mostly reported as mean wheal diameter obtained with one concentration of allergen. Differences in technique between personnel causes variation in wheal size. The research question was whether the influence of differences in skin prick test technique among assistants and centers can be reduced by relating the allergen wheal response to that of histamine. ...

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ژورنال

عنوان ژورنال: BMC Pulmonary Medicine

سال: 2015

ISSN: 1471-2466

DOI: 10.1186/s12890-015-0021-3